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Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases

Perihan A. Elzahhar, Shrouk M. Abd El Wahab, Mohamed Elagawany, Hoda G. Daabees, Ahmed S.F. Belal, Ahmed F. El‐Yazbi, Ali H. Eid, Rana Alaaeddine, Rehab Hegazy, Rasha M. Allam, Maged W. Helmy, Bahaa Elgendy, Andrea Angeli, Soad A. El-Hawash, Claudiu T. Supuran

2020European Journal of Medicinal Chemistry79 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryCarbonic anhydraseIn vivoEnzymeCell cycle checkpointApoptosisCell cultureCancer cellArachidonate 5-lipoxygenaseCell cycleBiochemistryA549 cellCancer researchCytotoxic T cellPharmacologyIn vitroCancerArachidonic acidBiologyBiotechnologyGeneticsEnzyme function and inhibitionSynthesis and Catalytic ReactionsSynthesis and biological activity
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases | Litcius