Analytical performance of the Xpert MTB/XDR® assay for tuberculosis and expanded resistance detection
Sophia B. Georghiou, Adam Penn‐Nicholson, Margaretha de Vos, Aurélien Macé, Melanie W. Syrmis, Kevin Jacob, Alyanna Mape, Heta Parmar, Yuan Cao, Chris Coulter, Morten Rühwald, Sushil Pandey, Samuel G. Schumacher, Claudia M. Denkinger
Abstract
In a manufacturer-independent laboratory validation study, the Xpert MTB/XDR® assay demonstrated equivalent limit of detection to Xpert MTB/RIF®, detected 100% of tested resistance mutations and showed some utility for resistance detection in strain mixtures. The Xpert MTB/XDR assay is a reliable, sensitive assay for tuberculosis and expanded resistance detection.
Topics & Concepts
TuberculosisDetection limitMycobacterium tuberculosisVirologyMedicineExtensively drug-resistant tuberculosisChromatographyChemistryPathologyTuberculosis Research and EpidemiologyMycobacterium research and diagnosisDiagnosis and treatment of tuberculosis