Human skeletal muscle possesses an epigenetic memory of high-intensity interval training
Andrea Pilotto, Daniel C. Turner, Raffaele Mazzolari, Emanuela Crea, Lorenza Brocca, Maria Antonietta Pellegrino, Danilo Miotti, Roberto Bottinelli, Adam P. Sharples, Simone Porcelli
Abstract
Cells possess a "memory" such that adaptations can be more quickly regained when a previously encountered challenge is reintroduced. Exercise provides an excellent experimental model to explore the concept of cellular memory to physiologically relevant stressors in humans. This study highlights molecular mechanisms that contribute to muscle memory in response to high-intensity interval training in humans, showing retention of DNA methylation and gene expression profiles from earlier training into detraining and retraining.
Topics & Concepts
EpigeneticsHigh-intensity interval trainingDNA methylationInterval trainingEndurance trainingSkeletal muscleAerobic exerciseRetrainingMethylationMedicineBioinformaticsGene expressionBiologyInternal medicineGeneGeneticsInternational tradeBusinessDiet and metabolism studiesBirth, Development, and HealthEpigenetics and DNA Methylation