Design, synthesis, and biological evaluation of novel arylcarboxamide derivatives as anti-tubercular agents
Shahinda S. R. Alsayed, Shichun Lun, Giuseppe Luna, Chau Chun Beh, Alan D. Payne, Neil R. Foster, William R. Bishai, Hendra Gunosewoyo
Abstract
(Vero cells) ≥ 227 μM], indicating their potential lack of cytotoxicity. The four compounds were docked into the MmpL3 active site and were studied for their drug-likeness using Lipinski's rule of five.
Topics & Concepts
AntimycobacterialIndole testCombinatorial chemistryChemistryCarboxamideStereochemistryTuberculosisMycobacterium tuberculosisMedicinePathologyTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsMycobacterium research and diagnosis