Genomic Investigation Reveals Contaminated Detergent as the Source of an Extended-Spectrum-β-Lactamase-Producing Klebsiella michiganensis Outbreak in a Neonatal Unit
Paul R. Chapman, Brian M. Forde, Leah W. Roberts, Haakon Bergh, Debra Vesey, Amy V. Jennison, Susan Moss, David L. Paterson, Scott A. Beatson, Patrick N. A. Harris
Abstract
Klebsiella species are problematic pathogens in neonatal units and may cause outbreaks, for which the sources of transmission may be challenging to elucidate. We describe the use of whole-genome sequencing (WGS) to investigate environmental sources of transmission during an outbreak of extended-spectrum-β-lactamase (ESBL)-producing Klebsiella michiganensis colonizing neonates. Ceftriaxone-resistant Klebsiella spp. isolated from neonates (or their mothers) and the hospital environment were included.
Topics & Concepts
OutbreakKlebsiellaKlebsiella pneumoniaeMicrobiologyBiologyTransmission (telecommunications)CeftriaxoneVirologyGeneticsEscherichia coliAntibioticsGeneElectrical engineeringEngineeringAntibiotic Resistance in BacteriaBacterial biofilms and quorum sensingEnterobacteriaceae and Cronobacter Research