Time-restricted feeding protects the blood pressure circadian rhythm in diabetic mice
Tianfei Hou, Wen Su, Marilyn J. Duncan, Vsevolozhskaya A. Olga, Zhenheng Guo, Ming Gong
Abstract
Significance This study investigates the cause and effect relationship between the timing of food intake and blood pressure (BP) circadian rhythm in diabetic db/db mice. The results show that nondipping BP is associated with the loss of food intake rhythm and imposing food intake rhythms by time-restricted feeding (TRF, food available only during active nighttime) protects BP dipping in db/db mice. Mechanistically, TRF suppressed the sympathetic activity during the resting daytime, thus protecting BP dipping in db/db mice. Our study reveals a critical role of the daily timing of food intake in the prevention and treatment of nondipping BP in diabetic mice. The utility of this approach to the treatment of hypertension in patients with diabetes remains to be determined.