Advances of dual-organ and multi-organ systems for gut, lung, skin and liver models in absorption and metabolism studies
Konstanze Brandauer, Sophie Schweinitzer, Alexandra Lorenz, Judith Krauß, Silvia Schobesberger, Martin Frauenlob, Peter Ertl
Abstract
models as well as microfluidic dual- and multi-organ systems are summarized with a focus on absorption (skin, lung, gut) and metabolism (liver). Additionally, the advantage of multi-organ chips in identifying a drug's on and off-target toxicity is discussed. Finally, the potential high-throughput implementation and modular chip design of multi-organ-on-a-chip systems within the pharmaceutical industry is highlighted, outlining the necessity of reducing handling complexity.
Topics & Concepts
Absorption (acoustics)Organ systemMetabolismLungMedicineBiologyPharmacologyPhysiologyPathologyInternal medicineMaterials scienceComposite materialDiseaseDiet and metabolism studiesAdipose Tissue and MetabolismClinical Nutrition and Gastroenterology