Treatment of a perforating dermatosis with apremilast
Josette R. McMichael, Benjamin K. Stoff
Abstract
Perforating dermatoses (PDs) are characterized by transepidermal elimination of dermal material. The 4 forms of PDs are as follows: acquired PD (includes Kyrle disease), reactive perforating collagenosis, perforating folliculitis (PF), and elastosis perforans serpiginosa (EPS).1 EPS affects approximately 1% of patients with Down syndrome and manifests as asymptomatic, erythematous, 2- to 5-mm keratotic, umbilicated papules in annular, arcuate, or serpiginous configurations. However, there may be a clinical and histologic overlap among the PD entities.
Topics & Concepts
MedicineDermatologyApremilastAsymptomaticDermal papillaePsoriasisPathologyPsoriatic arthritisInternal medicineHair follicleDermatological and Skeletal DisordersSkin and Cellular Biology ResearchWnt/β-catenin signaling in development and cancer