Design, synthesis and bioactivity evaluation of novel N-phenyl-substituted evodiamine derivatives as potent anti-tumor agents
Xiangyong Hao, Jiedan Deng, Honghua Zhang, Ziyi Liang, Lei Fang, Yuqing Wang, Xiaoyan Yang, Zhen Wang
Topics & Concepts
EvodiamineChemistryApoptosisIn vitroCell cultureLead compoundPI3K/AKT/mTOR pathwayCell growthCell cycle checkpointPharmacologyStereochemistryCell cycleProtein kinase BCancer researchBiochemistryMedicineBiologyGeneticsChromatographyQuinazolinone synthesis and applicationsSynthesis and Biological EvaluationCancer therapeutics and mechanisms