Enantioselective copper-catalyzed azidation/click cascade reaction for access to chiral 1,2,3-triazoles
Lingfeng Jiang, Shaohua Wu, Yuxuan Jiang, Hongxiang Ma, Jiajun He, Yang-Bo Bi, Deyi Kong, Yifei Cheng, Xuan Cheng, Qing‐Hai Deng
Abstract
Chiral 1,2,3-triazoles are highly attractive motifs in various fields. However, achieving catalytic asymmetric click reactions of azides and alkynes for chiral triazole synthesis remains a significant challenge, mainly due to the limited catalytic systems and substrate scope. Herein, we report an enantioselective azidation/click cascade reaction of N-propargyl-β-ketoamides with a readily available and potent azido transfer reagent via copper catalysis, which affords a variety of chiral 1,2,3-triazoles with up to 99% yield and 95% ee under mild conditions. Notably, chiral 1,5-disubstituted triazoles that have not been accessed by previous asymmetric click reactions are also prepared with good functional group tolerance.