Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress
Marisa Loi, Maurizio Molinari
Abstract
Physiological and pathological stresses may cause swelling of the endoplasmic reticulum (ER), a biosynthetic organelle in eukaryotic cells. Upon conclusion of the stress, ER size and content return to physiological levels. The translocon component SEC62 decorates the portions of excess ER that must be cleared from cells. Our recent paper highlights the role of endosomal sorting complex required for transport (ESCRT)-III-driven micro-ER-phagy in ER remodeling during cell recovery from ER stress.
Topics & Concepts
Endoplasmic reticulumUnfolded protein responseCell biologyEndosomeOrganelleAutophagyBiologyBiochemistryIntracellularApoptosisEndoplasmic Reticulum Stress and DiseaseAutophagy in Disease and TherapyCellular transport and secretion