Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal
Timothy M. Doyle, Tally M. Largent‐Milnes, Zhoumou Chen, Vasiliki Staikopoulos, Emanuela Esposito, Rebecca Dalgarno, Churmy Y. Fan, Dilip K. Tosh, Salvatore Cuzzocrea, Kenneth A. Jacobson, Tuan Trang, Mark R. Hutchinson, Gary J. Bennett, Todd W. Vanderah, Daniela Salvemini
Topics & Concepts
Adenosine kinaseMedicineHyperalgesiaMorphineAdenosineNociceptionPharmacologyOpioid(+)-NaloxoneAdenosine receptorChronic painDrug toleranceAgonistPurinergic signallingReceptorInternal medicineAdenosine deaminasePsychiatryPain Mechanisms and TreatmentsAdenosine and Purinergic SignalingPharmacological Receptor Mechanisms and Effects