Remote Nucleophilic Substitution at a C(sp3)–H Bond of α-Bromocarboxamides via 1,4-Hydrogen Atom Transfer To Access N-Acyl-N,O-acetal Compounds

Daisuke Shimizu, Ayako Kurose, Takashi Nishikata

2022Organic Letters13 citationsDOI

Abstract

reaction with various α-bromocarboxamides via chemoselective reactions.

Topics & Concepts

ChemistryNucleophilic substitutionMoleculeAcetalNucleophileAlcoholMedicinal chemistryHydrogen bondHydrogen atomCatalysisStereochemistryOrganic chemistryGroup (periodic table)Synthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsChemical Synthesis and Analysis

Remote Nucleophilic Substitution at a C(sp<sup>3</sup>)–H Bond of α-Bromocarboxamides via 1,4-Hydrogen Atom Transfer To Access <i>N</i>-Acyl-<i>N</i>,<i>O</i>-acetal Compounds

Abstract

Topics & Concepts