Ribosome stalling is a signal for metabolic regulation by the ribotoxic stress response
Goda Snieckute, Aitana Victoria Genzor, Anna Vind, Laura Ryder, Mark Stoneley, Sébastien Chamois, René Dreos, Cathrine Nordgaard, Frederike Sass, Melanie Blasius, Aida Rodríguez López, Sólveig Hlín Brynjólfsdóttir, Kasper Langebjerg Andersen, Anne E. Willis, Lisa B. Frankel, Steen Seier Poulsen, David Gatfield, Zachary Gerhart‐Hines, Christoffer Clemmensen, Simon Bekker‐Jensen
Abstract
male mice present a lean phenotype. Our work highlights impaired ribosomes as metabolic signals and demonstrates a role for RSR signaling in metabolic regulation.
Topics & Concepts
Metabolic pathwayFight-or-flight responseIntegrated stress responseCell biologySignal transductionSignal pathwayBiologyTranslation (biology)Computational biologyChemistryBioinformaticsGeneticsBiochemistryMetabolismMessenger RNAGeneEndoplasmic Reticulum Stress and DiseaseDiet, Metabolism, and DiseaseMicrobial Metabolic Engineering and Bioproduction