Synthesis of Indole-Fused Six-, Seven-, or Eight-Membered N,O-Heterocycles via Rhodium-Catalyzed <i>NH</i>-Indole-Directed C–H Acetoxylation/Hydrolysis/Annulation
Guoshuai Pan, Leipeng Lu, Weihui Zhuang, Qiufeng Huang
Abstract
We report herein the facile synthesis of indole-fused six-, seven-, or eight-membered N,O-heterocycles through rhodium-catalyzed C–H acetoxylation/hydrolysis/annulation. The notable features of this method include C–H acetoxylation using NH-indole as the intrinsic directing group, high functional group compatibility, and construction of indole-fused medium-sized rings.
Topics & Concepts
Indole testAnnulationChemistryRhodiumHydrolysisCatalysisStereochemistryOrganic chemistryMedicinal chemistryCombinatorial chemistryCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsAsymmetric Hydrogenation and Catalysis