Metformin activates the PI3K/AKT/BDNF axis to attenuate postoperative cognitive dysfunction
Qing Wu, Xiao-Yu Jia, Shi-hua Zhang, Yu‐Hsuan Wu, Longsheng Xu, J. Han, Wei Yu, Qinghe Zhou
Topics & Concepts
MetforminPostoperative cognitive dysfunctionMedicinePI3K/AKT/mTOR pathwayNeuroprotectionNeurotrophic factorsNeuroinflammationBrain-derived neurotrophic factorPharmacologyProtein kinase BMorris water navigation taskIsofluraneLY294002AnesthesiaHippocampusEndocrinologyInternal medicineApoptosisChemistryInflammationCognitionDiabetes mellitusPsychiatryReceptorBiochemistryIntensive Care Unit Cognitive DisordersAnesthesia and Neurotoxicity ResearchCancer-related cognitive impairment studies