Palladium-catalyzed direct γ-C(sp<sup>3</sup>)–H arylation of β-alkoxy cyclohexenones: reaction scope and mechanistic insights
Li‐Dong Shao, Yang Chen, Mei Wang, Nan Xiao, Zhi‐Jun Zhang, Dashan Li, Rong‐Tao Li
Abstract
Direct γ-C(sp 3 )-arylation of unactivated electron-rich enones remains a challenge. We have found a Pd-catalyzed method for direct γ-C(sp 3 )-arylation of unactivated β-alkoxy cyclohexenones which enables the synthesis of bioactive CBD-like compounds.
Topics & Concepts
ChemistryAlkoxy groupCatalysisPalladiumScope (computer science)Combinatorial chemistryMedicinal chemistryOrganic chemistryProgramming languageComputer scienceAlkylCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsRadical Photochemical Reactions