Highly cytotoxic, cyclometalated iridium(<scp>iii</scp>)-5-fluoro-8-quinolinol complexes as cancer cell mitochondriotropic agents
Li-Qin Qin, Bi‐Qun Zou, Qi‐Pin Qin, Zhenfeng Wang, Lin Yang, Ming‐Xiong Tan, Chun-Jie Liang, Hong Liang
Abstract
<bold>Ir-3</bold> and <bold>Ir-4</bold> kill HeLa cells and trigger caspase-mediated mitochondrial dysfunction apoptosis pathways.
Topics & Concepts
ChemistryIridiumCytotoxic T cellCombinatorial chemistryCancer cell linesCancerCancer cellStereochemistryBiochemistryIn vitroCatalysisMedicineInternal medicineMetal complexes synthesis and propertiesCancer therapeutics and mechanismsElectron Spin Resonance Studies