Molecular Coevolution of Nuclear and Nucleolar Localization Signals inside the Basic Domain of HIV-1 Tat
Margarita A. Kurnaeva, Arthur O. Zalevsky, Eugene A. Arifulin, Olga M. Lisitsyna, Anna V. Tvorogova, Maria Y. Shubina, Gleb Bourenkov, Maria A. Tikhomirova, Daria M. Potashnikova, Anastasia I. Kachalova, Yana R. Musinova, Andrey V. Golovin, Yegor Vassetzky, Eugene V. Sheval
Abstract
) and found that these two supplementary functions (i.e., function of NLS and function of NoLS) are embedded in the basic domain amino acid sequence. The integration of NLSs and NoLSs into functional domains of viral proteins enriched with positively charged amino acids is a mechanism that allows the concentration of different functions within small protein regions. Integration of NLS and NoLS into functional protein domains might have influenced the viral evolution, as this could prevent an increase in the protein size.