Transcriptional dysregulation of TRIM29 promotes colorectal cancer carcinogenesis via pyruvate kinase-mediated glucose metabolism
Jing Han, Zitong Zhao, Nan Zhang, Yang Yang, Liying Ma, Feng Li, Xue Zhang, Jing Zuo, Zhisong Fan, Yudong Wang, Yongmei Song, Guiying Wang
Abstract
. Mechanistic analyses indicate that TRIM29 promotes pyruvate kinase (mainly PKM1) degradation via the ubiquitin-proteasome pathway. TRIM29 directly targets PKM1 to reduce PKM1/PKM2 ratio, which results in PKM2-mediated aerobic glycolysis (Warburg effect) acting as the dominant energy source in CRC. Our findings suggest that TRIM29 acts as a tumor promoter in CRC, especially in RSCC, and is a potential therapeutic target for CRC treatment.
Topics & Concepts
Pyruvate kinaseColorectal cancerCarcinogenesisCancer researchKinaseCarbohydrate metabolismMetabolismBiologyChemistryGlycolysisCell biologyCancerBiochemistryGeneticsinterferon and immune responsesImmune cells in cancerCancer Mechanisms and Therapy