Copper and Copper Complexes in Tumor Therapy
Yingqiao Wang, Tingxi Tang, Yi Yuan, Nan Li, Xiaoqing Wang, Jian Guan
Abstract
Copper (Cu), a crucial trace element in physiological processes, has garnered significant interest for its involvement in cancer progression and potential therapeutic applications. The regulation of cellular copper levels is essential for maintaining copper homeostasis, as imbalances can lead to toxicity and cell death. The development of drugs that target copper homeostasis has emerged as a promising strategy for anticancer treatment, with a particular focus on copper chelators, copper ionophores, and novel copper complexes. Recent research has also investigated the potential of copper complexes in cancer therapy.
Topics & Concepts
CopperCancer therapyHomeostasisChemistryCopper toxicityCancer researchCancerMedicineCell biologyBiologyInternal medicineOrganic chemistryMetal complexes synthesis and propertiesDrug Transport and Resistance MechanismsNanoparticle-Based Drug Delivery