Redox-Neutral 1,4-Dicarbonfunctionalization of 1,3-Butadiene by Merging Photoredox and Nickel Catalysis
Ding Du, Lian‐Feng Fan, Zhi‐Yong Han, Pu‐Sheng Wang
Abstract
The diverse functionalization of 1,3-butadiene provides wide applicability toward the synthesis of abundant and useful allylic compounds. Here, we describe a three-component and redox-neutral assembly of readily available C═X compounds, 1,3-butadiene, and various nucleophiles by merging photoredox and nickel catalysis, enabling the rapid synthesis of structurally diverse homoallyl amines and homoallylic alcohols.
Topics & Concepts
ChemistryNickelCatalysisRedoxNucleophilePhotoredox catalysisAllylic rearrangementCombinatorial chemistrySurface modificationPhotochemistryOrganic chemistryPhotocatalysisPhysical chemistryCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsRadical Photochemical Reactions