IL-38 inhibits microglial inflammatory mediators and is decreased in amygdala of children with autism spectrum disorder
Irene Tsilioni, Harry Pantazopoulos, Pio Conti, Susan E. Leeman, Theoharis C. Theoharides
Abstract
Significance These findings indicate the important role of IL-38 in the inihibition of neurotensin-stimulated activation of microglia and the resulting release of proinflammatory molecules. Moreover, the reduced expression of IL-38 in the amygdala indicates that it may not be sufficient to prevent inflammation, and that its administration could serve as a novel treatment for children with autism spectrum disorder.
Topics & Concepts
Proinflammatory cytokineMicrogliaAutism spectrum disorderNeurotensinAmygdalaAutismNeuroinflammationInflammationNeurosciencePsychologyMedicineImmunologyDevelopmental psychologyNeuropeptideInternal medicineReceptorAutism Spectrum Disorder ResearchNeuroendocrine regulation and behaviorStress Responses and Cortisol