Synthesis and biological evaluation of 4-(pyridin-4-oxy)-3-(3,3-difluorocyclobutyl)-pyrazole derivatives as novel potent transforming growth factor-β type 1 receptor inhibitors
Guofeng Xu, Yan Zhang, Hai Wang, Zhuang Guo, Xiaowei Wang, Xue Li, Shaohua Chang, Tianwen Sun, Zhuangzhuang Yu, Tianwei Xu, Liwen Zhao, Yazhou Wang, Wenying Yu
Topics & Concepts
ChemistryPyrazoleTransforming growth factorIn vivoBioavailabilityPharmacologyIC50Cell growthReceptorEx vivoIn vitroGrowth inhibitionStereochemistryBiochemistryInternal medicineBiologyMedicineBiotechnologyTGF-β signaling in diseasesGrowth Hormone and Insulin-like Growth FactorsCell Adhesion Molecules Research