Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458
Yu-Fan Chen, Yi-Shuan J. Li, Chih‐Hung Chou, Men Yee Chiew, Hsien‐Da Huang, Jennifer Hui‐Chun Ho, Shu Chien, Oscar K. Lee
Abstract
Mechanical cues from matrix stiffness regulate endodermal fate of pluripotent stem cells via the long noncoding RNA 000458.
Topics & Concepts
Cell biologyLong non-coding RNAMatrix (chemical analysis)BiologyStiffnessInduced pluripotent stem cellRNALineage (genetic)Computational biologyChemistryEmbryonic stem cellGeneticsGenePhysicsThermodynamicsChromatographyCancer-related molecular mechanisms researchRNA Research and SplicingRNA modifications and cancer