An innovative NRF2 nano-modulator induces lung cancer ferroptosis and elicits an immunostimulatory tumor microenvironment
Chih-Hsiung Hsieh, Hung-Chia Hsieh, Fu-Hsuan Shih, Pei‐Wen Wang, Li‐Xing Yang, Dar-Bin Shieh, Yi‐Ching Wang
Abstract
This dual-functional nanomedicine established an effective strategy to synergistically induce ferroptotic cancer cell death and reprogram the immunosuppressive microenvironment, which highlights the potential of ZVI-NP as an advanced integrated anti-cancer strategy.
Topics & Concepts
Tumor microenvironmentCancer researchLung cancerCancerLungChemistryMedicineTumor cellsPathologyInternal medicineFerroptosis and cancer prognosisCancer Immunotherapy and BiomarkersEpigenetics and DNA Methylation