Effect of monosodium glutamate on serum sex hormones and uterine histology in female rats along with its molecular docking and in-silico toxicity
Mahfoudh A. M. Abdulghani, Salah Abdalrazak Alshehade, Sareh Kamran, Mohammed Abdullah Alshawsh
Abstract
) was smaller than the control group. MSG showed high-affinity binding to acetylcholine receptors and disrupted the normal nerve signal with a predicted LD50 of 4500 mg/kg. MSG also demonstrated good binding affinity to human oestrogen receptors beta and some other proteins that have an oxidative stress role in the female reproductive organs. Therefore, a precaution should be taken when utilising this compound, especially for females under the risk factor of hormonal abnormality.
Topics & Concepts
Monosodium glutamateHormoneGlutamate receptorToxicityReceptorReproductive toxicityInternal medicineEndocrinologyBiologyIn vivoUterusIn vitroPharmacologyBiochemistryMedicineBiotechnologyBiochemical Analysis and Sensing TechniquesFatty Acid Research and HealthRegulation of Appetite and Obesity