USP18 and USP20 restrict oHSV-1 replication in resistant human oral squamous carcinoma cell line SCC9 and affect the viability of SCC9 cells
Ruitao Lu, Guangxian Wu, Meiling Chen, Dongmei Ji, Yonghong Liu, Grace Guoying Zhou, Wenmin Fu
Abstract
. The results showed that the combination of GSK2643934A and T1012G treatment brought a profound anti-tumor efficacy in mice bearing SCC9 tumors. This report explored factors that play roles in mediating oHSV-1 replication in OSCC tumor cells, facilitating to offer potential targets to improve oHSV-1 oncolytic efficacy and develop candidates of biomarkers to predict the efficiency of oHSV-1 multiplication in tumors.
Topics & Concepts
Oncolytic virusViral replicationVirusBiologyCancer researchCell cultureDeubiquitinating enzymeVirologyUbiquitinGeneGeneticsVirus-based gene therapy researchinterferon and immune responsesHerpesvirus Infections and Treatments