Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells
Qiuyan Guo, Enshe Jiang
Abstract
Podophyllotoxins, including epipodophyllotoxin derivatives, can act on a diverse array of drug targets in cancer cells and thus possess potent activity against various forms of cancer cell lines, including drug-resistant forms. Moreover, several podophyllotoxin derivatives represented by etoposide and teniposide, have already been approved for cancer therapy, demonstrating podophyllotoxin moiety as a useful pharmacophore for the discovery of novel anticancer agents. This review reports the recent advances in the exploitation of podophyllotoxin derivatives to fight against multidrug-resistant cancer cells. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted.
Topics & Concepts
PodophyllotoxinTeniposidePharmacophoreEtoposideCancer cellMultiple drug resistanceCancer therapyComputational biologyDrugCancerCancer cell linesPharmacologyChemistryBiologyBiochemistryStereochemistryAntibioticsChemotherapyGeneticsPlant-derived Lignans Synthesis and BioactivityBiological Activity of Diterpenoids and BiflavonoidsSynthesis and biological activity