Aggregative Adherence Fimbriae II of Enteroaggregative Escherichia coli Are Required for Adherence and Barrier Disruption during Infection of Human Colonoids
Laura A. Gonyar, Rachel M. Smith, Jorge A. Girón, Nicholas C. Zachos, Fernando Ruı́z-Pérez, James P. Nataro
Abstract
Symptomatic and asymptomatic infection with the diarrheal pathogen enteroaggregative Escherichia coli (EAEC) is associated with growth faltering in children in developing settings. The mechanism of this association is unknown, emphasizing a need for better understanding of the interactions between EAEC and the human gastrointestinal mucosa. In this study, we investigated the role of the aggregative adherence fimbriae II (AAF/II) in EAEC adherence and pathogenesis using human colonoids and duodenal enteroids.
Topics & Concepts
Enteroaggregative Escherichia coliFimbriaMicrobiologyBiologyPathogenPathogenesisHuman pathogenEscherichia coliDiarrheaEnterobacteriaceaeAsymptomaticImmunologyVirologyBacteriaMedicinePathologyBiochemistryGeneticsGeneChild Nutrition and Feeding IssuesChild Nutrition and Water AccessInfant Nutrition and Health