<i>Fusobacterium nucleatum</i> promotes colorectal cancer cells adhesion to endothelial cells and facilitates extravasation and metastasis by inducing ALPK1/NF-κB/ICAM1 axis
Ying Zhang, Lu Zhang, Sheng Zheng, Mengjie Li, Chaochao Xu, Dingjiacheng Jia, Yadong Qi, Tongyao Hou, Lan Wang, Boya Wang, Aiqing Li, Shujie Chen, Jianmin Si, Wei Zhuo
Abstract
in tumor tissues of CRC patients was positively associated with the expression levels of ALPK1 and ICAM1. Moreover, high expression of ALPK1 or ICAM1 was significantly associated with a shorter overall survival time of CRC patients. This study provides a new insight into the role of gut microbiota in engaging into the distant metastasis of CRC cells.
Topics & Concepts
Fusobacterium nucleatumExtravasationMetastasisColorectal cancerCancer researchBiologyDownregulation and upregulationLeukocyte extravasationCell adhesionCancerImmunologyCell adhesion moleculeCellGeneticsGeneBacteriaPorphyromonas gingivalisBiochemistryGut microbiota and healthBarrier Structure and Function StudiesMycobacterium research and diagnosis