Schiff-Based Metal Complexes of Lamotrigine: Design, Synthesis, Characterization, and Biological Evaluation
Saima Najm, Humaira Naureen, Kishwar Sultana, Fareeha Anwar, Muhammad Mubbashir Khan, Humaira Nadeem, Muhammad Saeed
Abstract
) were found to possess the most potent anticancer, anticonvulsant, and neurotoxic potential than lamotrigine alone.
Topics & Concepts
Dihydrofolate reductaseProtein Data Bank (RCSB PDB)ChemistrySchiff baseLamotrigineStereochemistryNeurotoxicityLead compoundDocking (animal)Combinatorial chemistryEnzymeIn vitroBiochemistryOrganic chemistryBiologyToxicityMedicineNursingEpilepsyNeuroscienceMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsComputational Drug Discovery Methods