Discovery of a novel covalent CDK4/6 inhibitor based on palbociclib scaffold
Huifang Shan, Xinyu Ma, Guoyi Yan, Meng Luo, Xin-Xin Zhong, Suke Lan, Jie Yang, Yuanyuan Liu, Chunlan Pu, Tong Yu, Rui Li
Topics & Concepts
PalbociclibChemistryScaffoldCovalent bondKinaseCyclin-dependent kinase 4Cyclin-dependent kinaseCell growthSelectivityIn vitroPharmacologyCell cycleBiochemistryCellCancerCyclin-dependent kinase 2Protein kinase AInternal medicineBiologyMedicineOrganic chemistryMetastatic breast cancerBreast cancerBiomedical engineeringCatalysisAdvanced Breast Cancer TherapiesHER2/EGFR in Cancer ResearchCancer therapeutics and mechanisms