Mechanisms and Functions of Mitophagy and Potential Roles in Renal Disease
Zhenying Zuo, Kaipeng Jing, H. Wu, Shujun Wang, Lin Ye, Zhihang Li, Chen Yang, Qingjun Pan, Wei Jing Liu, Huafeng Liu
Abstract
Mitophagy is an evolutionarily conserved process to selectively remove damaged or unnecessary mitochondria via the autophagic machinery. In this review, we focus on recent advances in the molecular mechanisms of mitophagy and how mitophagy contributes to cellular homeostasis in physiological and pathological contexts. We also briefly review and discuss the crosstalk between mitophagy and renal disease, highlighting its modulation as a potentially effective therapeutic strategy to treat kidney diseases such as acute kidney injury (AKI), diabetic kidney disease (DKD), and lupus nephritis (LN).
Topics & Concepts
MitophagyAutophagyCrosstalkLupus nephritisDiseaseKidney diseaseKidneyPathologicalMedicineMitochondrionBioinformaticsBiologyNeuroscienceCell biologyInternal medicineGeneticsApoptosisEngineeringElectronic engineeringAutophagy in Disease and TherapyLysosomal Storage Disorders ResearchHeme Oxygenase-1 and Carbon Monoxide