CD44 Gene rs8193 C Allele Is Significantly Enriched in Gastric Cancer Patients.
Roya Mokhtarian, Hossein Tabatabaeian, Pardis Saadatmand, Mansoureh Azadeh, Negar Balmeh, Bagher Yakhchali, Kamran Ghaedi
Abstract
OBJECTIVE: gene, has not been studied in gastric cancer patients of the Iranian population. The present study aims to study this polymorphism in 86 gastric cancer patients and 96 healthy individuals. MATERIALS AND METHODS: In this cross-sectional case-control study, rs8193 polymorphism was genotyped by allele specific primer polymerase chain reaction (ASP-PCR) technique. The obtained data were statistically analyzed. To find the potential mechanism of action, rs8193 was bioinformatically investigated. RESULTS: and miR-570 interaction. CONCLUSION: rs8193 is statistically associated with the risk of malignancy, lymph node spread and stage of gastric cancer in Iranian population.