Synthesis, biological evaluation and molecular docking studies of novel pyrrolo[2,3-d]pyrimidin-2-amine derivatives as EGFR inhibitors
G. Sivaiah, R. Raveesha, S. Prasad, K. Yogesh Kumar, M.S. Raghu, Fahad A. Alharti, M.K. Prashanth, Byong‐Hun Jeon
Topics & Concepts
ChemistryPyrimidineDocking (animal)IC50StereochemistryLipinski's rule of fiveEpidermal growth factor receptorIn vitroAmine gas treatingAmideEGFR inhibitorsCytotoxicityCombinatorial chemistryCytotoxic T cellBiochemistryReceptorOrganic chemistryGeneNursingIn silicoMedicineSynthesis and biological activityCancer therapeutics and mechanismsQuinazolinone synthesis and applications