Diversely functionalized isoquinolines and their core-embedded heterocyclic frameworks: a privileged scaffold for medicinal chemistry
Archana Vijayakumar, M Manod, Raveendran Bharath Krishna, Abra Mathew, Chithra Mohan
Abstract
This review will be an essential toolbox for medicinal and bioorganic chemists seeking novel multifunctional hybrid and bioactive N-heterocycles for drug discovery. The work highlights the need for and relevance of unexplored bioisosterism employing isoquinoline-based small-molecules in drug design.
Topics & Concepts
IsoquinolineChemistryEnantiopure drugCombinatorial chemistryAtom economyMoleculeDrug discoveryOrganic synthesisNanotechnologyEnantioselective synthesisOrganic chemistryMaterials scienceCatalysisBiochemistrySynthesis and biological activitySynthesis of heterocyclic compoundsSynthesis and Characterization of Heterocyclic Compounds