Catalytic Diastereospecific and Enantioselective (3 + 2) Transannulations of 1,2,3-Thiadiazoles with Strained Norbornene Derivatives
Cunzhi Chen, Shuyan Fang, Ziyang Dong, Jiaxi Xu, Zhanhui Yang
Abstract
With the adoption of a ring-strain-release strategy, iridium-catalyzed transannulations with norbornene derivatives are achieved in a diastereospecific and enantioselective manner. The first asymmetric transannulations of 1,2,3-thiadiazoles are reported.
Topics & Concepts
Enantioselective synthesisThiadiazolesNorborneneChemistryIridiumCatalysisRing strainRing (chemistry)StereochemistryCombinatorial chemistryOrganic chemistryPolymerizationPolymerCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions