A Coumarin–Porphyrin FRET Break-Apart Probe for Heme Oxygenase-1
Edward R. H. Walter, Ying Ge, Justin C. Mason, Joseph J. Boyle, Nicholas J. Long
Abstract
, we have shown that close structural analogues of heme are required to maintain HO-1 activity. It is anticipated that this work will act as a foundation to design and develop new probes for HO-1 activity in the future, moving toward applications of live fluorescent imaging.
Topics & Concepts
ChemistryPorphyrinHemeFluorophoreHeme oxygenaseCoumarinFörster resonance energy transferBiophysicsEnzymeFluorescenceHemeproteinBiochemistryPhotochemistryOrganic chemistryPhysicsBiologyQuantum mechanicsHeme Oxygenase-1 and Carbon MonoxideHemoglobin structure and functionNeonatal Health and Biochemistry