Regulation of aging-related chronic diseases by dietary polyphenols: An updated overview
Jingying Liu, Kexin Dong, Qiuyu Deng, Zhichao Zou, Siqi Chen, Nianjie Feng, Jingyi Wang, Huang Huang, Qian Wu
Abstract
With the aging of the population, diseases of aging such as Alzheimer's disease, diabetes and coronary heart disease are gradually becoming a key concern in global health. Dietary polyphenols, as a natural antioxidant with biological activities such as anti-inflammatory, anti-glycation, and anticancer, can effectively prevent and treat these diseases through a variety of mechanisms. However, the current means of prevention and control for these age-related diseases are still insufficient, especially the lack of reviews and studies on systematic regulation from a dietary perspective. Therefore, in this paper, we will review the bioactivity of dietary polyphenols and their regulatory mechanisms on aging-related diseases, the relationship between dietary polyphenols and cell signaling pathways and the microbiome, and the creation of polyphenol-based functional anti-aging foods, so as to provide new ideas and methods for the intervention of geriatric diseases from the perspective of dietary regulation. • Provide a comprehensive summary of the biological activities in dietary polyphenols. • Explore the deeper mechanisms by which dietary polyphenols exert regulatory effects on aging-related diseases. • Reveal the important role of dietary polyphenols in health promotion and disease remission. • Develop deeper mechanisms overcoming bioavailability/stability barriers for precise anti-aging interventions.