Litcius/Paper detail

Mechanochemical Electrophilic Mono- or Disulfur Transfer: Construction of P(O)–S or P(O)–S–S Bonds

Ziwu Zhang, Tianfeng Lao, Lichan Deng, Chen Zhang, Jubin Liu, Minyue Fu, Zhengquan Su, Yue Yu, Hua Cao

2022Organic Letters21 citationsDOI

Abstract

Under mechanochemically induced conditions, a wide range of diarylphosphine oxides or H-phosphonates react with trisulfide dioxides to afford various thiophosphate derivatives in good yields. Selective S–S bond cleavage of trisulfide dioxides determined by connecting groups is proposed as the key step in the construction of P(O)–S or P(O)–S–S bonds, which is supported by calculations.

Topics & Concepts

ChemistryElectrophileMedicinal chemistryTransfer (computing)StereochemistryPolymer chemistryPhotochemistryOrganic chemistryCatalysisParallel computingComputer scienceSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods