Potent macrocycle inhibitors of the human SAGA deubiquitinating module
Michael T. Morgan, Tatsuya Ikenoue, Hiroaki Suga, Cynthia Wolberger
Topics & Concepts
Deubiquitinating enzymeHistone H2BUbiquitinAcetyltransferaseProtein subunitBiologyHistone acetyltransferaseEnzymePhage displayBiochemistryCoactivatorMolecular biologyHistoneChemistryPeptideAcetylationGeneTranscription factorUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsGlycosylation and Glycoproteins Research