Advances in small-molecule fluorescent probes for the study of apoptosis
Ya‐Xi Ye, Jian-Cheng Pan, Haichao Wang, Xingtao Zhang, Hai‐Liang Zhu, Xinhua Liu
Abstract
have attracted broad interest in related disease diagnostics and therapeutics. In this review, we aim to highlight the recent developments of SMFPs based on enzyme activity, plasma membranes, reactive oxygen species, reactive sulfur species, microenvironments and others during cell apoptosis. In particular, we generalize the mechanisms commonly used to design SMFPs for studying apoptosis. In addition, we discuss the limitations of reported probes, and emphasize the potential challenges and prospects in the future. We believe that this review will provide a comprehensive summary and challenging direction for the development of SMFPs in apoptosis related fields.
Topics & Concepts
FluorescenceMoleculeApoptosisSmall moleculeChemistryBiophysicsNanotechnologyMaterials scienceBiologyBiochemistryPhysicsOpticsOrganic chemistryMolecular Sensors and Ion DetectionLuminescence and Fluorescent MaterialsRNA Interference and Gene Delivery