Elevated post-ischemic ubiquitination results from suppression of deubiquitinase activity and not proteasome inhibition
Timo Kahles, Carrie Poon, Liping Qian, Victoria Palfini, Shanmukha Priya Srinivasan, Shilpa Swaminathan, Ismary Blanco, Reunet Rodney-Sandy, Costantino Iadecola, Ping Zhou, Karin Hochrainer
Topics & Concepts
UbiquitinDeubiquitinating enzymeProteostasisProteasomeIschemiaNeuroprotectionCell biologyChemistryUbiquitin-conjugating enzymeLactacystinUbiquitin ligaseBiochemistryProteasome inhibitorBiologyPharmacologyInternal medicineMedicineGeneUbiquitin and proteasome pathwaysMitochondrial Function and PathologyAutophagy in Disease and Therapy