Electrochemically C–H/S–H Oxidative Cross-Coupling between Quinoxalin-2(1<i>H</i>)-ones and Thiols for the Synthesis of 3-Thioquinoxalinones
Jiadi Zhou, Zhonghui Li, Zexu Sun, Quanlei Ren, Qi‐Wei Zhang, Hu Li, Jianjun Li
Abstract
An electrochemical method for the C(sp2)–H thioetherification of quinoxalin-2(1H)-ones with primary, secondary, and tertiary thiols has been reported. Various quinoxalin-2(1H)-ones underwent this thioetherification smoothly under metal- and chemical oxidant-free conditions, affording 3-alkylthiol-substituted quinoxalin-2(1H)-ones in moderate to good yields.
Topics & Concepts
ElectrochemistryChemistryOxidative phosphorylationPrimary (astronomy)MetalCoupling (piping)Combinatorial chemistryMedicinal chemistryStereochemistryOrganic chemistryBiochemistryMaterials sciencePhysical chemistryElectrodeMetallurgyPhysicsAstronomySulfur-Based Synthesis TechniquesSynthesis and Biological EvaluationCatalytic C–H Functionalization Methods