Anti-EGFR VHH-armed death receptor ligand–engineered allogeneic stem cells have therapeutic efficacy in diverse brain metastatic breast cancers
Yohei Kitamura, Nobuhiko Kanaya, Susana Moleirinho, Wanlu Du, Clemens Reinshagen, Nada Attia, Agnieszka Bronisz, Esther Revai Lechtich, Hikaru Sasaki, Joana L. Mora, Priscilla K. Brastianos, Jeffrey L. Falcone, Aldebaran M. Hofer, Arnaldo Franco, Khalid Shah
Abstract
secreting stem cells alleviated tumor-burden and significantly increased survival in mouse models of residual-tumor after macrometastasis resection, perivascular niche micrometastasis, and leptomeningeal metastasis. This study reports mechanism based simultaneous targeting of EGFR and DR4/5 in BLBC and defines a new treatment paradigm for treatment of BM.
Topics & Concepts
MicrometastasisMedicineCancer researchMetastatic breast cancerStem cellBreast cancerCancer stem cellCancerInternal medicineBiologyGeneticsBrain Metastases and TreatmentLung Cancer Research StudiesProtein Degradation and Inhibitors