Evaluation of the Disconnect between Hepatocyte and Microsome Intrinsic Clearance and In Vitro In Vivo Extrapolation Performance
Beth Williamson, Stephanie Harlfinger, Dermot F. McGinnity
Topics & Concepts
In vivoHepatocyteMicrosomeIn vitroExtrapolationMicrosomaChemistryCell biologyPharmacologyBiologyBiochemistryGeneticsMathematicsMathematical analysisLiver physiology and pathologyPancreatic function and diabetesPancreatic and Hepatic Oncology Research