Flux balance analysis and peptide mapping elucidate the impact of bioreactor pH on Chinese hamster ovary (CHO) cell metabolism and N-linked glycosylation in the fab and Fc regions of the produced IgG
Jayanth Venkatarama Reddy, Sumit Kumar Singh, Thomas Leibiger, Kelvin H. Lee, Marianthi Ierapetritou, Eleftherios T. Papoutsakis
Topics & Concepts
Chinese hamster ovary cellGlycosylationBioreactorFlux (metallurgy)Peptide mappingMetabolismBiochemistryMetabolic flux analysisBiologyChemistryFlux balance analysisOvaryHamsterMolecular biologyBotanyGeneGeneticsPeptide sequenceReceptorOrganic chemistryViral Infectious Diseases and Gene Expression in InsectsProtein purification and stabilityMonoclonal and Polyclonal Antibodies Research