Challenges of short substrate analogues as SARS-CoV-2 main protease inhibitors
Sven Ullrich, Vishnu Mini Sasi, Mithun C. Mahawaththa, Kasuni B. Ekanayake, Richard Morewood, Josemon George, Laura Shuttleworth, Xiaobai Zhang, Cassidy Whitefield, Gottfried Otting, Colin J. Jackson, Christoph Nitsche
Topics & Concepts
PeptidomimeticProteaseChemistryDrug discoveryProteasesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PeptideStructure–activity relationshipCoronavirus disease 2019 (COVID-19)BiochemistryStereochemistryComputational biologyEnzymeBiologyIn vitroMedicinePathologyInfectious disease (medical specialty)DiseaseSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery Methodsvaccines and immunoinformatics approaches