The gut virome in association with the bacteriome in gastrointestinal diseases and beyond: roles, mechanisms, and clinical applications
Zhiyang Feng, Elke Burgermeister, Anna Philips, Tao Zuo, Weijie Wen
Abstract
The gut virome, an essential component of the intestinal microbiome, constitutes ∼0.1% of the total microbial biomass but contains a far greater number of particles than bacteria, with phages making up 90%-95% of this virome. This review systematically examines the developmental patterns of the gut virome, focusing on factors influencing its composition, including diet, environment, host genetics, and immunity. Additionally, it explores the gut virome's associations with various diseases, its interactions with gut bacteria and the immune system, and its emerging clinical applications.
Topics & Concepts
Human viromeBiologyAssociation (psychology)GeneticsPsychologyMetagenomicsPsychotherapistGeneViral gastroenteritis research and epidemiologyClostridium difficile and Clostridium perfringens researchBacteriophages and microbial interactions